SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6guo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6guo -
(-) 		3 / 3 SER A 262
GLU A 263
GLU A 259
 None
 0.62A 1eqbD-6guoA:
undetectable		 1eqbD-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6guo -
(-) 		3 / 3 SER A 262
GLU A 263
GLU A 259
 None
 0.63A 1eqbB-6guoA:
undetectable		 1eqbB-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6guo -
(-) 		5 / 12 LEU A 270
LEU A 174
ALA A 170
PHE A 297
LEU A 301
 None
 0.91A 2h42C-6guoA:
undetectable		 2h42C-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 6guo -
(-) 		5 / 12 HIS A 163
ASP A  58
GLY A 284
HIS A 283
SER A 222
 None
 1.43A 2pgfA-6guoA:
undetectable		 2pgfA-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 6guo -
(-) 		4 / 6 ARG A 244
SER A 285
ASP A 280
PRO A 230
 CL  A 404 (-3.3A)
None
None
CL  A 404 ( 4.8A)
 1.44A 3jqaB-6guoA:
4.4		 3jqaB-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 6guo -
(-) 		5 / 9 LEU A 185
PHE A 161
VAL A  54
ALA A  66
THR A  69
 None
 1.19A 3mdtA-6guoA:
undetectable		 3mdtA-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 6guo -
(-) 		5 / 12 TYR A 165
GLY A 167
SER A 164
ILE A 191
LEU A 160
 None
 1.08A 3q87B-6guoA:
undetectable		 3q87B-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 6guo -
(-) 		4 / 8 PHE A 169
ILE A 198
GLU A 201
LEU A 134
 None
 0.83A 3rqwI-6guoA:
undetectable
3rqwJ-6guoA:
undetectable		 3rqwI-6guoA:
undetectable
3rqwJ-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 6guo -
(-) 		5 / 10 LEU A 185
PHE A 161
VAL A  54
ALA A  66
THR A  69
 None
 1.01A 4j14A-6guoA:
undetectable		 4j14A-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6guo -
(-) 		5 / 11 ALA A 170
LEU A 174
GLU A 201
LEU A 264
LEU A 270
 None
 1.17A 4wg0G-6guoA:
undetectable
4wg0H-6guoA:
undetectable
4wg0I-6guoA:
undetectable		 4wg0G-6guoA:
undetectable
4wg0H-6guoA:
undetectable
4wg0I-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 6guo -
(-) 		3 / 3 TYR A 278
ARG A 220
LYS A 276
 None
 0.95A 4wq5B-6guoA:
undetectable		 4wq5B-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 6guo -
(-) 		4 / 6 TYR A  30
ASP A  27
TYR A  90
TYR A 103
 None
 1.38A 5e2iA-6guoA:
13.2		 5e2iA-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 6guo -
(-) 		5 / 12 GLY A 294
ILE A 295
PHE A 161
TYR A 278
LEU A  56
 None
 1.27A 5nz0A-6guoA:
undetectable		 5nz0A-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 6guo -
(-) 		5 / 12 ALA A  53
LEU A  70
TRP A  40
VAL A  34
PHE A  63
 None
 1.23A 5vlmE-6guoA:
undetectable		 5vlmE-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 6guo -
(-) 		3 / 3 ARG A 220
PHE A 161
GLY A 294
 None
 0.76A 6fgdA-6guoA:
2.6		 6fgdA-6guoA:
undetectable