SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 6gup -
(-) 		5 / 12 LEU A 236
HIS A 121
HIS A 326
TYR A 222
ILE A 171
 None
 1.25A 1fmlA-6gupA:
undetectable		 1fmlA-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 6gup -
(-) 		4 / 5 LEU A  71
VAL A  23
TYR A  18
THR A  72
 None
 1.26A 1nw3A-6gupA:
undetectable		 1nw3A-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6gup -
(-) 		4 / 5 GLN A 172
TRP A 291
VAL A 292
SER A 166
 None
 1.39A 1p6kB-6gupA:
undetectable		 1p6kB-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 6gup -
(-) 		3 / 3 TRP A 173
VAL A 288
PRO A 289
 None
 0.73A 1rg1A-6gupA:
undetectable		 1rg1A-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 6gup -
(-) 		3 / 3 TRP A 173
VAL A 288
PRO A 289
 None
 0.71A 1rh0A-6gupA:
undetectable		 1rh0A-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6gup -
(-) 		4 / 4 GLN A 172
TRP A 291
VAL A 292
SER A 166
 None
 1.37A 1rs6A-6gupA:
0.0		 1rs6A-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6gup -
(-) 		4 / 5 GLN A 172
TRP A 291
VAL A 292
SER A 166
 None
 1.36A 1rs6B-6gupA:
undetectable		 1rs6B-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6gup -
(-) 		4 / 5 GLN A 172
TRP A 291
VAL A 292
SER A 166
 None
 1.48A 1zzqB-6gupA:
undetectable		 1zzqB-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6gup -
(-) 		4 / 5 GLN A 172
TRP A 291
VAL A 292
SER A 166
 None
 1.46A 1zzuA-6gupA:
undetectable		 1zzuA-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6gup -
(-) 		4 / 5 GLN A 172
TRP A 291
VAL A 292
SER A 166
 None
 1.35A 1zzuB-6gupA:
undetectable		 1zzuB-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 6gup -
(-) 		5 / 12 GLY A  45
GLY A  43
ASP A  46
ALA A  49
ARG A 232
 None
 1.03A 2gluA-6gupA:
undetectable		 2gluA-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6gup -
(-) 		6 / 11 GLY A  45
GLY A  43
ASP A  46
ALA A  49
THR A  50
ARG A 232
 None
 1.32A 3g88A-6gupA:
undetectable		 3g88A-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6gup -
(-) 		6 / 11 GLY A  45
GLY A  43
ASP A  46
ALA A  49
THR A  50
ARG A 232
 None
 1.31A 3g88B-6gupA:
undetectable		 3g88B-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6gup -
(-) 		6 / 11 GLY A  45
GLY A  43
ASP A  46
ALA A  49
THR A  50
ARG A 232
 None
 1.31A 3g89B-6gupA:
undetectable		 3g89B-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6gup -
(-) 		6 / 12 GLY A  45
GLY A  43
ASP A  46
ALA A  49
THR A  50
ARG A 232
 None
 1.29A 3g8bA-6gupA:
undetectable		 3g8bA-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6gup -
(-) 		6 / 12 GLY A  45
GLY A  43
ASP A  46
ALA A  49
THR A  50
ARG A 232
 None
 1.27A 3g8bB-6gupA:
undetectable		 3g8bB-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 6gup -
(-) 		4 / 5 PRO A 239
SER A 241
LEU A 234
SER A 235
 None
 1.47A 3iluH-6gupA:
undetectable		 3iluH-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 6gup -
(-) 		3 / 3 TRP A 301
TRP A 314
THR A 305
 None
 1.33A 4bboB-6gupA:
undetectable		 4bboB-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 6gup -
(-) 		4 / 5 LEU A 273
LEU A 132
MET A 161
THR A 305
 None
 1.09A 4do3A-6gupA:
undetectable		 4do3A-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 6gup -
(-) 		5 / 12 SER A 125
GLY A  47
ASP A  46
PHE A  40
GLY A 120
 None
 1.14A 4pevB-6gupA:
5.9		 4pevB-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6gup -
(-) 		4 / 7 PHE A 264
SER A 133
ALA A 159
LEU A 277
 None
 1.10A 4xk8A-6gupA:
undetectable		 4xk8A-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 6gup -
(-) 		4 / 5 ASP A 293
VAL A 288
PHE A 281
GLY A 283
 None
 1.10A 4xp6A-6gupA:
undetectable		 4xp6A-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 6gup -
(-) 		4 / 6 PHE A 264
PHE A 281
GLU A 169
VAL A 288
 None
 1.24A 5h4dA-6gupA:
undetectable		 5h4dA-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6gup -
(-) 		4 / 5 GLN A 172
TRP A 291
VAL A 292
SER A 166
 None
 1.37A 5vunA-6gupA:
undetectable		 5vunA-6gupA:
undetectable