SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 6gw5 -
(-) 		5 / 11 PRO A 232
LEU A 238
VAL A  93
TYR A 100
GLY A  95
 None
 1.37A 1fkpA-6gw5A:
undetectable		 1fkpA-6gw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 6gw5 -
(-) 		5 / 11 PRO A 232
LEU A 238
VAL A  93
TYR A 100
GLY A  95
 None
 1.41A 1lwcA-6gw5A:
2.1		 1lwcA-6gw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6gw5 -
(-) 		5 / 12 ALA A 243
ILE A 247
VAL A  89
ALA A  88
ILE A 345
 None
 1.09A 2h42B-6gw5A:
undetectable		 2h42B-6gw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 6gw5 -
(-) 		5 / 12 ALA A 251
PHE A  69
ALA A  85
VAL A 349
GLY A 353
 None
 1.14A 2ve3B-6gw5A:
undetectable		 2ve3B-6gw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 6gw5 -
(-) 		5 / 11 LEU A 248
PHE A  83
SER A  80
VAL A  93
LEU A  94
 None
 1.26A 3a9eB-6gw5A:
undetectable		 3a9eB-6gw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 6gw5 -
(-) 		4 / 7 VAL A  43
LYS A  47
ILE A  50
GLN A  51
 None
 0.74A 3bjwB-6gw5A:
undetectable		 3bjwB-6gw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 6gw5 -
(-) 		4 / 5 VAL A 292
VAL A 356
GLY A 353
PHE A  69
 None
 0.97A 5d4nA-6gw5A:
undetectable
5d4nC-6gw5A:
undetectable		 5d4nA-6gw5A:
undetectable
5d4nC-6gw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 6gw5 -
(-) 		5 / 11 PRO A 232
LEU A 238
VAL A  93
TYR A 100
GLY A  95
 None
 1.38A 5hbmA-6gw5A:
undetectable		 5hbmA-6gw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 6gw5 -
(-) 		3 / 3 LEU A  94
GLN A 160
LYS A 150
 None
 0.99A 6exiA-6gw5A:
undetectable		 6exiA-6gw5A:
undetectable