SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 6gy5 -
(-) 		5 / 12 LEU A 379
HIS A 373
THR A 404
ASP A 374
GLY A 423
 NA  A 722 ( 4.4A)
None
None
NA  A 721 ( 4.8A)
None
 1.41A 1d4fA-6gy5A:
undetectable		 1d4fA-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 6gy5 -
(-) 		5 / 12 LEU A 379
HIS A 373
THR A 404
ASP A 374
GLY A 423
 NA  A 722 ( 4.4A)
None
None
NA  A 721 ( 4.8A)
None
 1.42A 1d4fC-6gy5A:
undetectable		 1d4fC-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6gy5 -
(-) 		5 / 10 GLY A 407
VAL A 418
GLY A 419
VAL A 455
HIS A 499
 None
None
None
None
NA  A 718 ( 4.9A)
 0.95A 1pwyE-6gy5A:
undetectable		 1pwyE-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6gy5 -
(-) 		5 / 10 GLY A 407
VAL A 418
GLY A 419
VAL A 455
HIS A 499
 None
None
None
None
NA  A 718 ( 4.9A)
 0.96A 1v3qE-6gy5A:
undetectable		 1v3qE-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 6gy5 -
(-) 		5 / 12 TYR A 510
GLY A 501
ALA A 454
ALA A 558
VAL A 512
 None
 1.24A 3nvkF-6gy5A:
undetectable
3nvkJ-6gy5A:
undetectable		 3nvkF-6gy5A:
undetectable
3nvkJ-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 6gy5 -
(-) 		5 / 12 LEU A 379
HIS A 373
THR A 404
ASP A 374
GLY A 423
 NA  A 722 ( 4.4A)
None
None
NA  A 721 ( 4.8A)
None
 1.48A 4lvcA-6gy5A:
undetectable		 4lvcA-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 6gy5 -
(-) 		5 / 12 LEU A 379
HIS A 373
THR A 404
ASP A 374
GLY A 423
 NA  A 722 ( 4.4A)
None
None
NA  A 721 ( 4.8A)
None
 1.48A 4lvcB-6gy5A:
undetectable		 4lvcB-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 6gy5 -
(-) 		5 / 12 GLY A 357
GLY A 594
GLY A 593
LEU A 592
GLY A 324
 None
EDO  A 710 (-3.2A)
EDO  A 710 (-3.6A)
EDO  A 702 (-4.1A)
None
 0.95A 4o3fA-6gy5A:
undetectable		 4o3fA-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6gy5 -
(-) 		3 / 3 ALA A 369
TYR A 368
PRO A 387
 None
 0.64A 4zdyA-6gy5A:
undetectable		 4zdyA-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6gy5 -
(-) 		3 / 3 ALA A 417
TYR A 416
PRO A 435
 None
None
EDO  A 704 ( 4.0A)
 0.68A 4zdyA-6gy5A:
undetectable		 4zdyA-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6gy5 -
(-) 		3 / 3 ALA A 464
TYR A 463
PRO A 482
 None
None
EDO  A 703 ( 4.9A)
 0.59A 4zdyA-6gy5A:
undetectable		 4zdyA-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 6gy5 -
(-) 		3 / 3 VAL A 443
THR A 441
ARG A 432
 None
None
EDO  A 703 (-3.0A)
 0.76A 5b2sB-6gy5A:
undetectable		 5b2sB-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 6gy5 -
(-) 		3 / 3 VAL A 443
THR A 441
ARG A 432
 None
None
EDO  A 703 (-3.0A)
 0.77A 5b2tB-6gy5A:
undetectable		 5b2tB-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 6gy5 -
(-) 		5 / 12 LEU A 379
HIS A 373
THR A 404
ASP A 374
GLY A 423
 NA  A 722 ( 4.4A)
None
None
NA  A 721 ( 4.8A)
None
 1.47A 5m5kA-6gy5A:
undetectable		 5m5kA-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 6gy5 -
(-) 		5 / 12 LEU A 379
HIS A 373
THR A 404
ASP A 374
GLY A 423
 NA  A 722 ( 4.4A)
None
None
NA  A 721 ( 4.8A)
None
 1.48A 5m5kB-6gy5A:
undetectable		 5m5kB-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6gy5 -
(-) 		5 / 12 LEU A 379
HIS A 373
THR A 404
ASP A 374
GLY A 423
 NA  A 722 ( 4.4A)
None
None
NA  A 721 ( 4.8A)
None
 1.45A 5v96A-6gy5A:
undetectable		 5v96A-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6gy5 -
(-) 		5 / 12 LEU A 379
HIS A 373
THR A 404
ASP A 374
GLY A 423
 NA  A 722 ( 4.4A)
None
None
NA  A 721 ( 4.8A)
None
 1.45A 5v96D-6gy5A:
undetectable		 5v96D-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 6gy5 -
(-) 		5 / 12 LEU A 320
GLY A 548
GLY A 595
GLY A 359
ARG A 355
 None
EDO  A 710 (-3.3A)
EDO  A 710 (-3.2A)
None
None
 1.04A 6ce2B-6gy5A:
undetectable		 6ce2B-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 6gy5 -
(-) 		5 / 12 LEU A 556
GLY A 501
GLY A 548
GLY A 595
ARG A 591
 None
None
EDO  A 710 (-3.3A)
EDO  A 710 (-3.2A)
None
 1.12A 6ce2B-6gy5A:
undetectable		 6ce2B-6gy5A:
undetectable