SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 6gzp NANOBODY
(Lama
glama) 		4 / 7 ASN A  33
TYR A 100
ARG A  71
ALA A  49
 None
 1.07A 3frqB-6gzpA:
undetectable		 3frqB-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 6gzp NANOBODY
(Lama
glama) 		5 / 12 ALA A  24
MET A  34
ARG A  71
ASN A  76
ALA A  94
 None
 0.88A 3qxtA-6gzpA:
21.8		 3qxtA-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 6gzp NANOBODY
(Lama
glama) 		5 / 12 VAL A   2
ALA A  24
MET A  34
ARG A  71
ALA A  94
 None
 0.83A 3qxtA-6gzpA:
21.8		 3qxtA-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 6gzp NANOBODY
(Lama
glama) 		7 / 12 VAL A   2
LEU A   4
ALA A  24
MET A  34
ARG A  71
ALA A  94
TYR A 102
 None
 0.68A 3qxtB-6gzpA:
22.0		 3qxtB-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6gzp NANOBODY
(Lama
glama) 		7 / 12 VAL A   2
ALA A  24
MET A  34
ARG A  71
ASN A  73
ALA A  94
TYR A 102
 None
 0.71A 3qxvA-6gzpA:
21.6		 3qxvA-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6gzp NANOBODY
(Lama
glama) 		6 / 12 VAL A   2
ALA A  24
MET A  34
ARG A  71
ALA A  94
TYR A 102
 None
 0.83A 3qxvB-6gzpA:
21.8		 3qxvB-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6gzp NANOBODY
(Lama
glama) 		6 / 11 VAL A   2
ALA A  24
MET A  34
ARG A  71
ASN A  73
ALA A  94
 None
 0.71A 3qxvC-6gzpA:
22.0		 3qxvC-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6gzp NANOBODY
(Lama
glama) 		6 / 12 VAL A   2
ALA A  24
MET A  34
ARG A  71
ALA A  94
TYR A 102
 None
 0.79A 3qxvD-6gzpA:
22.1		 3qxvD-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6gzp NANOBODY
(Lama
glama) 		5 / 12 ALA A  24
MET A  34
ARG A  71
ALA A  94
TYR A 102
 None
 0.83A 3qxvE-6gzpA:
18.4		 3qxvE-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6gzp NANOBODY
(Lama
glama) 		4 / 7 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.72A 5ecmD-6gzpA:
undetectable		 5ecmD-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6gzp NANOBODY
(Lama
glama) 		4 / 7 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.82A 5ecoD-6gzpA:
undetectable		 5ecoD-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 6gzp NANOBODY
(Lama
glama) 		3 / 3 LYS A 100
TRP A 103
SER A 100
 None
 1.10A 5nwwA-6gzpA:
undetectable		 5nwwA-6gzpA:
undetectable