SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6h25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 6h25 -
(-) 		4 / 7 ASN D  36
GLY D  43
ASP D  42
TYR D  59
 None
 0.93A 1bu5A-6h25D:
undetectable		 1bu5A-6h25D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6h25 -
(-) 		5 / 10 PHE B 107
ALA B  39
LEU B 228
VAL B 224
ILE B  41
 None
 1.20A 1claA-6h25B:
undetectable		 1claA-6h25B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 6h25 -
(-) 		3 / 3 GLN B 120
HIS B  56
PRO B  55
 None
 0.87A 1d8cA-6h25B:
undetectable		 1d8cA-6h25B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 6h25 -
(-) 		5 / 10 ALA D  62
VAL D  64
GLU D  69
ALA D  74
THR D  75
 None
 1.13A 1r55A-6h25D:
2.1		 1r55A-6h25D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 6h25 -
(-) 		5 / 12 VAL D 118
LEU D 134
VAL D 105
ALA D 140
LEU D 120
 None
 1.08A 1r9oA-6h25D:
undetectable		 1r9oA-6h25D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 6h25

(;
) 		5 / 12 PHE A 198
GLY A 219
GLY A 238
ILE B 196
LEU B 199
 None
 1.04A 1v2xA-6h25A:
undetectable		 1v2xA-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 6h25 -
(-) 		5 / 12 GLY D  43
VAL D 118
ALA D  56
ASP D 143
ALA D 140
 None
 1.23A 2avdB-6h25D:
undetectable		 2avdB-6h25D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 6h25 -
(-) 		4 / 8 LEU A  98
PRO A 209
GLY A 219
MET A 217
 None
 1.05A 2qd5B-6h25A:
undetectable		 2qd5B-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 6h25
() 		5 / 12 GLU A  49
ARG A  36
ALA A 285
PHE A 284
GLU D  34
 None
 1.18A 2vppA-6h25A:
undetectable		 2vppA-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 6h25
() 		5 / 12 GLU A  49
ARG A  36
ALA A 285
PHE A 284
GLU D  34
 None
 1.15A 2vppB-6h25A:
undetectable		 2vppB-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 6h25 -
(-) 		5 / 10 TYR D 224
PHE D 221
ALA D 184
THR D 101
VAL D 105
 None
 1.35A 2wuzA-6h25D:
undetectable		 2wuzA-6h25D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 6h25 -
(-) 		4 / 4 LEU B 228
ARG B  23
LEU B  22
ALA B 137
 None
 1.11A 3b9mA-6h25B:
undetectable		 3b9mA-6h25B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6h25 -
(-) 		4 / 7 LEU A  98
PRO A 209
GLY A 219
MET A 217
 None
 1.03A 3hcnA-6h25A:
undetectable		 3hcnA-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 6h25

(;
) 		3 / 3 THR A  72
LYS B   6
GLU A 119
 None
 0.86A 3ijdB-6h25A:
undetectable		 3ijdB-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6h25

(;
) 		3 / 3 SER A 237
GLY A 238
GLN B 105
 None
 0.54A 3v4tH-6h25A:
undetectable		 3v4tH-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 6h25
() 		4 / 8 ARG A 229
GLU B 207
GLU A 230
ARG B 204
 None
 1.18A 4bqfB-6h25A:
undetectable		 4bqfB-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 6h25 -
(-) 		3 / 3 LYS A  21
THR A  29
ILE A 253
 None
 0.76A 4e0fB-6h25A:
undetectable		 4e0fB-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 6h25 -
(-) 		3 / 3 LEU A  80
MET A 106
ASP A 142
 None
 0.69A 4j7xB-6h25A:
undetectable		 4j7xB-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 6h25 -
(-) 		4 / 6 ARG A  27
ASP A  25
LEU A  50
SER A 195
 None
 1.15A 4ot2A-6h25A:
undetectable		 4ot2A-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 6h25 -
(-) 		3 / 3 VAL D 155
PHE D 221
ARG D 190
 None
 0.80A 4xr4B-6h25D:
undetectable		 4xr4B-6h25D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 6h25 -
(-) 		5 / 11 LEU A 157
ALA A 153
LEU A 110
LEU A  76
LEU A  80
 None
 1.46A 5hyrB-6h25A:
undetectable		 5hyrB-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 6h25 -
(-) 		3 / 3 CYH A 115
LYS A 114
HIS A 188
 None
 0.88A 5js5A-6h25A:
undetectable		 5js5A-6h25A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 6h25 -
(-) 		3 / 3 ASN D 135
TYR D 224
CYH D  33
 None
 0.94A 5lsuB-6h25D:
undetectable		 5lsuB-6h25D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6h25 -
(-) 		5 / 9 HIS B 235
VAL B 231
VAL B 232
LEU B 144
ALA B  39
 None
 1.14A 5tt3B-6h25B:
undetectable		 5tt3B-6h25B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6h25 -
(-) 		4 / 8 HIS B 235
VAL B 231
LEU B 144
ALA B  39
 None
 0.89A 5tt3H-6h25B:
undetectable		 5tt3H-6h25B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 6h25 -
(-) 		5 / 12 VAL A  59
LEU A  76
LEU A 110
ILE A 154
ALA A 153
 None
 1.47A 5xprA-6h25A:
undetectable		 5xprA-6h25A:
undetectable