SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7mdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		5 / 11 ALA A 157
ALA A  50
LEU A  83
SER A  52
VAL A 166
 None
 1.15A 1ictA-7mdhA:
undetectable
1ictC-7mdhA:
undetectable		 1ictA-7mdhA:
17.83
1ictC-7mdhA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		5 / 11 LEU A 158
ALA A  50
LEU A  83
SER A  52
VAL A 166
 None
 1.15A 1ictA-7mdhA:
undetectable
1ictC-7mdhA:
undetectable		 1ictA-7mdhA:
17.83
1ictC-7mdhA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		5 / 9 SER A  59
GLY A  56
ALA A  91
LEU A  92
GLY A  84
 None
 1.31A 1jb0A-7mdhA:
undetectable		 1jb0A-7mdhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 6 ASN A 147
GLY A  53
ILE A 129
ILE A 150
 None
 0.88A 1n49D-7mdhA:
undetectable		 1n49D-7mdhA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 8 PHE A  64
SER A  59
ALA A  96
LEU A  99
 None
 1.03A 2o01A-7mdhA:
undetectable		 2o01A-7mdhA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		5 / 12 ASN A 176
PHE A 324
PRO A 235
LEU A 385
SER A 355
 None
None
None
ZN  A 503 (-4.0A)
None
 0.84A 2xrlA-7mdhA:
undetectable		 2xrlA-7mdhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 5 GLN A 208
THR A 198
HIS A 229
LEU A 385
 None
None
ZN  A 501 (-2.9A)
ZN  A 503 (-4.0A)
 1.40A 2zj0A-7mdhA:
undetectable		 2zj0A-7mdhA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		3 / 3 ASN A 173
ASN A 176
GLU A 362
 ZN  A 501 (-3.7A)
None
None
 0.93A 3kpdB-7mdhA:
undetectable		 3kpdB-7mdhA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		5 / 9 SER A  59
GLY A  56
ALA A  91
LEU A  92
GLY A  84
 None
 1.32A 3pcqA-7mdhA:
undetectable		 3pcqA-7mdhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		5 / 9 ASN A 314
VAL A 309
GLY A 227
ILE A 352
PRO A 327
 None
 1.33A 3spkA-7mdhA:
undetectable		 3spkA-7mdhA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 5 ASP A 115
GLU A 121
TYR A 117
ASP A 153
 None
ZN  A 504 (-2.2A)
None
None
 1.42A 3w9tD-7mdhA:
undetectable		 3w9tD-7mdhA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 5 GLN A 208
THR A 198
HIS A 229
LEU A 385
 None
None
ZN  A 501 (-2.9A)
ZN  A 503 (-4.0A)
 1.27A 4lvcA-7mdhA:
4.5		 4lvcA-7mdhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 5 GLN A 208
THR A 198
HIS A 229
LEU A 385
 None
None
ZN  A 501 (-2.9A)
ZN  A 503 (-4.0A)
 1.28A 4lvcC-7mdhA:
5.7		 4lvcC-7mdhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 7 ARG A 351
VAL A 234
LEU A 348
GLU A 350
 None
 1.02A 4zphA-7mdhA:
undetectable
4zphB-7mdhA:
undetectable		 4zphA-7mdhA:
22.69
4zphB-7mdhA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		3 / 3 ARG A 140
ASN A 228
ASP A 201
 None
None
ZN  A 503 ( 2.7A)
 0.60A 5gwxA-7mdhA:
4.9		 5gwxA-7mdhA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 5 ARG A 204
SER A 283
SER A 280
SER A 287
 None
 1.41A 5hswA-7mdhA:
undetectable		 5hswA-7mdhA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 8 ASN A 176
HIS A 229
ASN A 178
ARG A 140
 None
ZN  A 501 (-2.9A)
None
None
 1.16A 6b94A-7mdhA:
undetectable		 6b94A-7mdhA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 5 GLN A 208
THR A 198
HIS A 229
LEU A 385
 None
None
ZN  A 501 (-2.9A)
ZN  A 503 (-4.0A)
 1.22A 6gbnA-7mdhA:
6.4		 6gbnA-7mdhA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 7mdh PROTEIN (MALATE
DEHYDROGENASE)
(Sorghum
bicolor) 		4 / 5 GLN A 208
THR A 198
HIS A 229
LEU A 385
 None
None
ZN  A 501 (-2.9A)
ZN  A 503 (-4.0A)
 1.21A 6gbnD-7mdhA:
5.5		 6gbnD-7mdhA:
22.96