SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8fab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens) 		6 / 12 TYR A  35
GLN A  88
PHE A  97
VAL B  37
ALA B  97
TRP B 111
 None
 0.82A 1h8sA-8fabA:
17.8		 1h8sA-8fabA:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 8fab IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR A  35
PRO A  43
TYR A  86
TYR B  95
 None
 0.70A 2oldA-8fabA:
26.6
2oldB-8fabA:
20.8		 2oldA-8fabA:
76.04
2oldB-8fabA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 8fab IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B  95
TYR A  35
PRO A  43
TYR A  86
 None
 0.74A 2oldA-8fabB:
13.6
2oldB-8fabB:
17.2		 2oldA-8fabB:
32.03
2oldB-8fabB:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 8fab IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens) 		4 / 5 GLN A  30
ALA A  89
GLN A  88
ILE A  96
 None
 1.08A 2z0aA-8fabA:
undetectable		 2z0aA-8fabA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens) 		5 / 12 PHE B 174
SER A 175
VAL A 146
VAL A 144
PHE A 139
 None
 1.35A 3nbrA-8fabB:
undetectable		 3nbrA-8fabB:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens) 		5 / 12 PHE B 174
VAL A 195
VAL A 144
PRO A 113
PHE A 139
 None
 1.43A 3nbrA-8fabB:
undetectable		 3nbrA-8fabB:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
(Homo
sapiens) 		6 / 12 VAL B   2
ALA B  24
MET B  34
ARG B  72
ASN B  74
TYR B 110
 None
 1.02A 3qxvA-8fabB:
21.7		 3qxvA-8fabB:
59.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
(Homo
sapiens) 		5 / 12 VAL B   2
ALA B  24
MET B  34
ARG B  72
TYR B 110
 None
 0.96A 3qxvB-8fabB:
21.6		 3qxvB-8fabB:
59.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
(Homo
sapiens) 		5 / 11 VAL B   2
ALA B  24
MET B  34
ARG B  72
ASN B  74
 None
 0.79A 3qxvC-8fabB:
22.0		 3qxvC-8fabB:
59.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens) 		5 / 12 PHE B 106
HIS B  35
TRP B  47
PRO B 100
TYR A  33
 None
 1.48A 3whxA-8fabB:
24.0
3whxB-8fabB:
17.8		 3whxA-8fabB:
53.12
3whxB-8fabB:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 8fab IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens) 		4 / 8 THR A  73
TYR A  85
TRP A  34
ARG A  19
 None
 1.14A 3wipB-8fabA:
3.1
3wipC-8fabA:
3.1		 3wipB-8fabA:
23.38
3wipC-8fabA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 8fab IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens) 		4 / 8 THR A  73
TYR A  85
TRP A  34
ARG A  19
 None
 1.17A 3wipC-8fabA:
3.0
3wipD-8fabA:
3.1		 3wipC-8fabA:
23.38
3wipD-8fabA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
(Homo
sapiens) 		4 / 7 ALA B  92
THR B  91
VAL B 117
GLU B  89
 None
 0.73A 5ecmD-8fabB:
undetectable		 5ecmD-8fabB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
(Homo
sapiens) 		4 / 7 ALA B  92
THR B  91
VAL B 117
GLU B  89
 None
 0.82A 5ecoD-8fabB:
undetectable		 5ecoD-8fabB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens) 		4 / 5 TYR A  86
GLY A 100
THR A 101
GLY B 182
 None
 0.90A 5jlcA-8fabA:
undetectable		 5jlcA-8fabA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens) 		4 / 7 ASP B  99
PRO B 100
TYR A  48
PHE B 108
 None
 1.24A 5l1fC-8fabB:
undetectable		 5l1fC-8fabB:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
(Homo
sapiens) 		3 / 3 PRO B 193
SER B 194
SER B 195
 None
 0.58A 6bpyA-8fabB:
undetectable		 6bpyA-8fabB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
(Homo
sapiens) 		3 / 3 PRO B 193
SER B 195
SER B 196
 None
 0.69A 6bpyA-8fabB:
undetectable		 6bpyA-8fabB:
21.87