SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8pch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 8pch CATHEPSIN H
(Sus
scrofa) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 160
GLY A  65
 None
 1.26A 1stfE-8pchA:
32.4
1stfI-8pchA:
undetectable		 1stfE-8pchA:
40.44
1stfI-8pchA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 8pch CATHEPSIN H
(Sus
scrofa) 		7 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
ALA A 160
 None
 0.41A 1stfE-8pchA:
32.4
1stfI-8pchA:
undetectable		 1stfE-8pchA:
40.44
1stfI-8pchA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 8pch CATHEPSIN H
(Sus
scrofa) 		4 / 5 TYR A 149
SER A 153
SER A 151
THR A 138
 None
 1.16A 1yvpA-8pchA:
undetectable		 1yvpA-8pchA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 8pch CATHEPSIN H
(Sus
scrofa) 		4 / 6 TYR A 149
SER A 153
SER A 151
THR A 138
 None
 1.15A 1yvpB-8pchA:
undetectable		 1yvpB-8pchA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 8pch CATHEPSIN H
(Sus
scrofa) 		3 / 3 VAL A 110
ASP A 109
GLU A  73
 NAG  A 213 ( 4.5A)
None
NAG  A 213 ( 3.0A)
 0.73A 2qeuA-8pchA:
undetectable		 2qeuA-8pchA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 8pch CATHEPSIN H
(Sus
scrofa) 		3 / 3 VAL A 110
ASP A 109
GLU A  73
 NAG  A 213 ( 4.5A)
None
NAG  A 213 ( 3.0A)
 0.72A 2qeuC-8pchA:
undetectable		 2qeuC-8pchA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 8pch CATHEPSIN H
(Sus
scrofa) 		4 / 8 TRP A 181
TYR A 149
ARG A 145
MET A 183
 None
 1.10A 3wipB-8pchA:
undetectable
3wipC-8pchA:
undetectable		 3wipB-8pchA:
19.60
3wipC-8pchA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 8pch CATHEPSIN H
(Sus
scrofa) 		4 / 4 ASN A 198
ALA A 204
GLY A 201
THR A 155
 None
 1.25A 4bboC-8pchA:
undetectable		 4bboC-8pchA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 8pch CATHEPSIN H
(Sus
scrofa) 		4 / 4 LYS A  17
ASP A  55
GLU A  83
THR A  31
 None
 1.36A 5d4uA-8pchA:
undetectable		 5d4uA-8pchA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 8pch CATHEPSIN H
(Sus
scrofa) 		4 / 4 LYS A  17
ASP A  55
GLU A  83
THR A  31
 None
 1.37A 5d4uB-8pchA:
undetectable		 5d4uB-8pchA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 8pch CATHEPSIN H
(Sus
scrofa) 		4 / 4 LYS A  17
ASP A  55
GLU A  83
THR A  31
 None
 1.35A 5d4uC-8pchA:
undetectable		 5d4uC-8pchA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 8pch CATHEPSIN H
(Sus
scrofa) 		4 / 4 LYS A  17
ASP A  55
GLU A  83
THR A  31
 None
 1.35A 5d4uD-8pchA:
undetectable		 5d4uD-8pchA:
22.06